{"product_id":"illustrative-case-studies-in-haematology-red-cell-riddles","title":"Illustrative Case Studies in Haematology: Red Cell Riddles","description":"\u003cdiv data-cel-widget=\"bookDescription_feature_div\" data-csa-c-id=\"u7qumn-38oend-85jy7q-z9853p\" data-csa-c-is-in-initial-active-row=\"false\" data-csa-c-asin=\"\" data-csa-c-slot-id=\"bookDescription_feature_div\" data-csa-c-content-id=\"bookDescription\" data-csa-c-type=\"widget\" data-feature-name=\"bookDescription\" class=\"celwidget\" id=\"bookDescription_feature_div\"\u003e\n\u003cdiv class=\"a-expander-collapsed-height a-row a-expander-container a-spacing-base a-expander-partial-collapse-container\" data-a-expander-collapsed-height=\"280\" data-a-expander-name=\"book_description_expander\"\u003e\n\u003cdiv class=\"a-expander-content a-expander-partial-collapse-content\" data-expanded=\"false\"\u003e\n\u003cdiv id=\"bookDescription_feature_div\" class=\"celwidget\" data-feature-name=\"bookDescription\" 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class=\"celwidget\" id=\"bookDescription_feature_div\"\u003e\n\u003cdiv class=\"a-expander-collapsed-height a-row a-expander-container a-spacing-base a-expander-partial-collapse-container\" data-a-expander-collapsed-height=\"280\" data-a-expander-name=\"book_description_expander\"\u003e\n\u003cdiv class=\"a-expander-content a-expander-partial-collapse-content\" data-expanded=\"false\"\u003e\n\u003cdiv data-cel-widget=\"bookDescription_feature_div\" data-csa-c-id=\"ziezha-sub17o-6i3zsw-gei3xo\" data-csa-c-is-in-initial-active-row=\"false\" data-csa-c-asin=\"0367535807\" data-csa-c-slot-id=\"bookDescription_feature_div\" data-csa-c-content-id=\"bookDescription\" data-csa-c-type=\"widget\" data-feature-name=\"bookDescription\" class=\"celwidget\" id=\"bookDescription_feature_div\"\u003e\n\u003cdiv class=\"a-expander-collapsed-height a-row a-expander-container a-spacing-base a-expander-partial-collapse-container\" data-a-expander-collapsed-height=\"280\" data-a-expander-name=\"book_description_expander\"\u003e\n\u003cdiv class=\"a-expander-content a-expander-partial-collapse-content\" data-expanded=\"false\"\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan class=\"a-text-bold\"\u003eCase reports that illustrate a logical stepwise approach to the understanding of common and rare haematological problems\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan class=\"a-text-italic\"\u003eIllustrative Case Studies in Haematology\u003c\/span\u003e\u003cspan\u003e – \u003c\/span\u003e\u003cspan class=\"a-text-italic\"\u003eRed Cell Riddles\u003c\/span\u003e\u003cspan\u003e – is an educational book describing how the microscope, haematological findings, biochemical and molecular studies are used to reach a diagnosis. The book consists of 44 individual real-life case reports. Each case includes a brief clinical history, basic laboratory investigations, and initial impressions, leading to one or more possible diagnoses. Then, through more targeted investigations, the authors deliver a final diagnosis, which in most cases is at the molecular level.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eFor each case, a brief discussion is included, highlighting critical clinical and laboratory features, as well as recent progress in the area. Each individual case illustrates the close connection, in contemporary medicine, between clinical findings, haematological findings, and molecular analysis.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan class=\"a-text-italic\"\u003eIllustrative Case Studies in Haematology\u003c\/span\u003e\u003cspan\u003e includes:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul class=\"a-unordered-list a-vertical\"\u003e\n\u003cli\u003e\u003cspan class=\"a-list-item\"\u003e\u003cspan\u003ePatients with sickle cell disease, ranging from nearly asymptomatic to life-threatening\u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan class=\"a-list-item\"\u003e\u003cspan\u003ePatients with different forms of thalassaemia\u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan class=\"a-list-item\"\u003e\u003cspan\u003eKernicterus in a G6PD deficient female infant\u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan class=\"a-list-item\"\u003e\u003cspan\u003eAcquired alpha thalassaemia and myelodysplastic syndrome\u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan class=\"a-list-item\"\u003e\u003cspan\u003eParoxysmal nocturnal haemoglobinuria in a G6PD deficient patient\u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan class=\"a-list-item\"\u003e\u003cspan\u003eThe first case ever reported of homozygosity for an unstable haemoglobin\u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan class=\"a-list-item\"\u003e\u003cspan\u003eCases with long-term follow-up spanning decades, demonstrating disease progression, complications and therapeutic outcomes\u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan class=\"a-text-italic\"\u003eIllustrative Case Studies in Haematology\u003c\/span\u003e\u003cspan\u003e includes patients from many different countries: therefore it may hold value to haematologists throughout the world, seeking to diagnose both common and rare disorders with clarity and confidence. The book is also highly appropriate for trainee haematologists, biomedical scientists and medical students.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAbout the Author\u003c\/strong\u003e\u003cbr\u003eLucio Luzzatto received his MD from the University of Genova in 1959 and has held positions at universities in five countries in three continents. He is currently an honorary professor of haematology at the University of Florence; and a Foreign Member of the Accademia dei Lincei.\u003c\/p\u003e\n\u003cp\u003eDavid Roper has now retired from his role as Principal Biomedical Scientist at Hammersmith Hospital, Imperial College, London, UK. He has co-written several chapters in major textbooks.\u003c\/p\u003e\n\u003cp\u003e\u003cbr\u003e\u003cstrong\u003eTable of Contents\u003c\/strong\u003e\u003cbr\u003eForeword v\u003cbr\u003ePreface vii\u003cbr\u003eReference Ranges (adult) x\u003c\/p\u003e\n\u003cp\u003eList of Cases\u003c\/p\u003e\n\u003cp\u003e1. An active professional health worker with a serious genetic disorder 1\u003c\/p\u003e\n\u003cp\u003e2. Plot twist from clot missed 5\u003c\/p\u003e\n\u003cp\u003e3. Unstable: but stable 13\u003c\/p\u003e\n\u003cp\u003e4. Nurture and nature 23\u003c\/p\u003e\n\u003cp\u003e5. Patient knows best 29\u003c\/p\u003e\n\u003cp\u003e6. Not only males are affected 36\u003c\/p\u003e\n\u003cp\u003e7. A levels without haemoglobin A 42\u003c\/p\u003e\n\u003cp\u003e8. A hot blood smear 48\u003c\/p\u003e\n\u003cp\u003e9. More yellow than sick 58\u003c\/p\u003e\n\u003cp\u003e10. A blue baby with a normal heart 66\u003c\/p\u003e\n\u003cp\u003e11. Detecting and managing point mutations 73\u003c\/p\u003e\n\u003cp\u003e12. A gush of oxygen for the baby 83\u003c\/p\u003e\n\u003cp\u003e13. PA: not a Power-Act 91\u003c\/p\u003e\n\u003cp\u003e14. Sicily in my blood 99\u003c\/p\u003e\n\u003cp\u003e15. A storm of half-ghosts 106\u003c\/p\u003e\n\u003cp\u003e16. Honora medicum 112\u003c\/p\u003e\n\u003cp\u003e17. Failing to switch 123\u003c\/p\u003e\n\u003cp\u003e18. Rosettes without a trophy 130\u003c\/p\u003e\n\u003cp\u003e19. Too little beta and too much alpha 139\u003c\/p\u003e\n\u003cp\u003e20. Missing something you never knew you ought to have 146\u003c\/p\u003e\n\u003cp\u003e21. Two variants walk into a blood cell ... 154\u003c\/p\u003e\n\u003cp\u003e22. Low GPI, high GPA 159\u003c\/p\u003e\n\u003cp\u003e23. Split A2: a cue to Q 167\u003c\/p\u003e\n\u003cp\u003e24. A Celtic trait? 173\u003c\/p\u003e\n\u003cp\u003e25. Cold may not be cool 178\u003c\/p\u003e\n\u003cp\u003e26. When it rains, a microbe makes it pour 187\u003c\/p\u003e\n\u003cp\u003e27. Double membranes may prove ineffective 192\u003c\/p\u003e\n\u003cp\u003e28. Being less but being dominant 200\u003c\/p\u003e\n\u003cp\u003e29. Two enzymes down, still standing 208\u003c\/p\u003e\n\u003cp\u003e30. Sickle cell disease at 75 215\u003c\/p\u003e\n\u003cp\u003e31. Strong but frail 221\u003c\/p\u003e\n\u003cp\u003e32. Troublesome symbiotic relationship 231\u003c\/p\u003e\n\u003cp\u003e33. Not letting go 240\u003c\/p\u003e\n\u003cp\u003e34. Hellenic class A 247\u003c\/p\u003e\n\u003cp\u003e35. When the sickle stabs the kidney 255\u003c\/p\u003e\n\u003cp\u003e36. Dry cells, fake potassium, real iron 264\u003c\/p\u003e\n\u003cp\u003e37. Hb on target 275\u003c\/p\u003e\n\u003cp\u003e38. Too little beta and too little alpha 283\u003c\/p\u003e\n\u003cp\u003e39. Salt lake and salt bridges 290\u003c\/p\u003e\n\u003cp\u003e40. Small red cells with a difference 298\u003c\/p\u003e\n\u003cp\u003e41. Double jeopardy when facing complement 304\u003c\/p\u003e\n\u003cp\u003e42. Camden town: not just the market 313\u003c\/p\u003e\n\u003cp\u003e43. High on O2 and mutating again 320\u003c\/p\u003e\n\u003cp\u003e44. Epigenetic upheaval can make you alpha-broke 327\u003c\/p\u003e\n\u003cp\u003eFor a few of the titles in this list (only a few) we received help from ChatGPT, that we openly acknowledge. Initially we were surprised that AI could be witty: but of course AI has acquired 'data' from e.g. Terry Pratchett and P G Wodehouse, not just from Dante Alighieri and William Shakespeare.\u003c\/p\u003e\n\u003cp\u003eThis brings up a sticky issue: in the realm of science, is it advisable or even allowed to use ChatGPT at all? Our short answer is yes. A more articulate answer includes the following. (1) You can ask simple or complex questions, but you must always check ChatGPT's replies by finding and reading the original sources in the scientific literature. (2) You can broach a topic with ChatGPT just for the purpose of elaborating on your own ideas. (3) If you disagree with ChatGPT, consider it may be wrong: stick to your guns.\u003c\/p\u003e\n\u003cp\u003eArtificial intelligence should stimulate, not thwart natural intelligence.\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"celwidget aplus-module module-12 aplus-standard\" data-cel-widget=\"aplus-module-12\" data-csa-c-id=\"e48qwb-36wm3s-vb6e8j-pnxs9b\"\u003e\n\u003cdiv class=\"aplus-module-wrapper apm-spacing apm-floatnone apm-fixed-width\"\u003e\n\u003cdiv class=\"apm-sidemodule aplus-module-content\"\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003e1. No Risk, 30-Day Money-Back Guarantee. \u003cbr\u003e2. instant download. 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