{"product_id":"molecular-recognition-in-pharmacology-drugs-and-the-pharmaceutical-sciences-1st-edition","title":"Molecular Recognition in Pharmacology (Drugs and the Pharmaceutical Sciences) 1st Edition","description":"\u003cdiv data-cel-widget=\"bookDescription_feature_div\" data-csa-c-id=\"7y9w7h-rgk3d4-2xixgp-6jetc1\" data-csa-c-is-in-initial-active-row=\"false\" data-csa-c-asin=\"0993745598\" data-csa-c-slot-id=\"bookDescription_feature_div\" data-csa-c-content-id=\"bookDescription\" data-csa-c-type=\"widget\" data-feature-name=\"bookDescription\" class=\"celwidget\" id=\"bookDescription_feature_div\"\u003e\n\u003cdiv class=\"a-expander-collapsed-height a-row a-expander-container a-spacing-base a-expander-partial-collapse-container\" data-a-expander-collapsed-height=\"280\" data-a-expander-name=\"book_description_expander\"\u003e\n\u003cdiv class=\"a-expander-content a-expander-partial-collapse-content\" aria-expanded=\"false\"\u003e\n\u003cdiv id=\"bookDescription_feature_div\" class=\"celwidget\" data-feature-name=\"bookDescription\" data-csa-c-type=\"widget\" data-csa-c-content-id=\"bookDescription\" data-csa-c-slot-id=\"bookDescription_feature_div\" data-csa-c-asin=\"1975136373\" data-csa-c-is-in-initial-active-row=\"false\" data-csa-c-id=\"3xu427-hdulpm-xey1d9-kajk0v\" data-cel-widget=\"bookDescription_feature_div\"\u003e\n\u003cdiv data-a-expander-name=\"book_description_expander\" data-a-expander-collapsed-height=\"280\" class=\"a-expander-collapsed-height a-row a-expander-container a-spacing-base a-expander-partial-collapse-container\"\u003e\n\u003cdiv aria-expanded=\"false\" class=\"a-expander-content a-expander-partial-collapse-content\"\u003e\n\u003cdiv id=\"bookDescriptionBox\" class=\"expanded\"\u003e\n\u003cdiv data-cel-widget=\"bookDescription_feature_div\" data-csa-c-id=\"h4cphk-6mo8ox-v0de30-bzc1ph\" data-csa-c-is-in-initial-active-row=\"false\" data-csa-c-asin=\"\" data-csa-c-slot-id=\"bookDescription_feature_div\" data-csa-c-content-id=\"bookDescription\" data-csa-c-type=\"widget\" data-feature-name=\"bookDescription\" class=\"celwidget\" id=\"bookDescription_feature_div\"\u003e\n\u003cdiv class=\"a-expander-collapsed-height a-row a-expander-container a-spacing-base a-expander-partial-collapse-container\" data-a-expander-collapsed-height=\"280\" data-a-expander-name=\"book_description_expander\"\u003e\n\u003cdiv class=\"a-expander-content a-expander-partial-collapse-content\" data-expanded=\"false\"\u003e\n\u003cdiv data-cel-widget=\"bookDescription_feature_div\" data-csa-c-id=\"h4cphk-6mo8ox-v0de30-bzc1ph\" data-csa-c-is-in-initial-active-row=\"false\" data-csa-c-asin=\"\" data-csa-c-slot-id=\"bookDescription_feature_div\" data-csa-c-content-id=\"bookDescription\" data-csa-c-type=\"widget\" data-feature-name=\"bookDescription\" class=\"celwidget\" id=\"bookDescription_feature_div\"\u003e\n\u003cdiv class=\"a-expander-collapsed-height a-row a-expander-container a-spacing-base a-expander-partial-collapse-container\" data-a-expander-collapsed-height=\"280\" data-a-expander-name=\"book_description_expander\"\u003e\n\u003cdiv class=\"a-expander-content a-expander-partial-collapse-content\" data-expanded=\"false\"\u003e\n\u003cdiv id=\"bookDescription_feature_div\" class=\"celwidget\" data-feature-name=\"bookDescription\" data-csa-c-type=\"widget\" data-csa-c-content-id=\"bookDescription\" data-csa-c-slot-id=\"bookDescription_feature_div\" data-csa-c-asin=\"3031583507\" data-csa-c-is-in-initial-active-row=\"false\" data-csa-c-id=\"n4mbr1-rfgl5j-54k8tz-xjddri\" data-cel-widget=\"bookDescription_feature_div\"\u003e\n\u003cdiv data-a-expander-name=\"book_description_expander\" data-a-expander-collapsed-height=\"280\" class=\"a-expander-collapsed-height a-row a-expander-container a-spacing-base a-expander-partial-collapse-container\"\u003e\n\u003cdiv data-expanded=\"false\" class=\"a-expander-content a-expander-partial-collapse-content\"\u003e\n\u003cdiv id=\"bookDescription_feature_div\" class=\"celwidget\" data-feature-name=\"bookDescription\" data-csa-c-type=\"widget\" data-csa-c-content-id=\"bookDescription\" data-csa-c-slot-id=\"bookDescription_feature_div\" data-csa-c-asin=\"3030615065\" data-csa-c-is-in-initial-active-row=\"false\" data-csa-c-id=\"3qt2m8-ejwa7d-btjx7e-24p9sf\" data-cel-widget=\"bookDescription_feature_div\"\u003e\n\u003cdiv data-a-expander-name=\"book_description_expander\" data-a-expander-collapsed-height=\"280\" class=\"a-expander-collapsed-height a-row a-expander-container a-spacing-base a-expander-partial-collapse-container\"\u003e\n\u003cdiv data-expanded=\"false\" class=\"a-expander-content a-expander-partial-collapse-content\"\u003e\n\u003cp\u003e\u003cspan\u003eThis unique volume traces the behavior of the drug substance, starting from the initial pre-contact stage, and ending with the formation of the complex. Molecular recognition lies in the foundation of every life form and includes many mysteries. Currently, studies on this topic in pharmacology are limited to determining the properties of complexes of medicinal substances (drugs) with specific (complementary) biomolecules: receptors, enzymes, ion channels etc. The results present the mechanisms preventing drugs from such non-specific binding. This direction is very fruitful, although the phenomenon of molecular recognition is far wider.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan class=\"a-text-bold\"\u003eFeatures\u003c\/span\u003e\u003c\/p\u003e\n\u003cul class=\"a-unordered-list a-vertical\"\u003e\n\u003cli\u003e\u003cspan class=\"a-list-item\"\u003e\u003cspan\u003ePresents the basics of thermodynamics and kinetics of complex formation between ligands and receptors\u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan class=\"a-list-item\"\u003e\u003cspan\u003eSelected novel therapeutic concepts are tested and validated\u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan class=\"a-list-item\"\u003e\u003cspan\u003eProvides a review of the pharmacophore approach and drug design methods\u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan class=\"a-list-item\"\u003e\u003cspan\u003eBy its nature, pharmacology is a multi-disciplinary science, hence, disciplinary areas include chemistry, biology and neuroscience\u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cspan class=\"a-list-item\"\u003e\u003cspan\u003eDiscusses hot topics including 3D structure determination techniques and in silico methods and neural networks\u003c\/span\u003e\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan\u003eThe main theme of the book is the consideration of mechanisms created by nature to protect physiologically active substances from being stuck on nonspecific acceptors in the body. The book describes the materials that aid in the development of new medicinal substances. It is intended for researchers, as well as upper-level undergraduate and graduate students interested in the problems of molecular pharmacology and drug design.\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv id=\"globalStoreInfoBullets_feature_div\" class=\"celwidget\" data-feature-name=\"globalStoreInfoBullets\" data-csa-c-type=\"widget\" data-csa-c-content-id=\"globalStoreInfoBullets\" data-csa-c-slot-id=\"globalStoreInfoBullets_feature_div\" data-csa-c-asin=\"3030615065\" data-csa-c-is-in-initial-active-row=\"false\" data-csa-c-id=\"aoc45y-b1aeb7-gjezxy-6oi6m1\" data-cel-widget=\"globalStoreInfoBullets_feature_div\"\u003e\u003c\/div\u003e\n\u003cdiv id=\"buyingOptionNostosBadge_feature_div\" class=\"celwidget\" data-feature-name=\"buyingOptionNostosBadge\" data-csa-c-type=\"widget\" data-csa-c-content-id=\"buyingOptionNostosBadge\" data-csa-c-slot-id=\"buyingOptionNostosBadge_feature_div\" data-csa-c-asin=\"3030615065\" data-csa-c-is-in-initial-active-row=\"false\" data-csa-c-id=\"l86odb-h4l9si-kcnyc0-2l172e\" data-cel-widget=\"buyingOptionNostosBadge_feature_div\"\u003e\u003c\/div\u003e\n\u003cdiv id=\"tellAmazon_feature_div\" class=\"celwidget\" data-feature-name=\"tellAmazon\" data-csa-c-type=\"widget\" data-csa-c-content-id=\"tellAmazon\" data-csa-c-slot-id=\"tellAmazon_feature_div\" data-csa-c-asin=\"3030615065\" data-csa-c-is-in-initial-active-row=\"false\" data-csa-c-id=\"l39lw7-7wk4en-z467j7-ewszhq\" data-cel-widget=\"tellAmazon_feature_div\"\u003e\n\u003cdiv class=\"celwidget c-f\" data-csa-op-log-render=\"\" data-csa-c-content-id=\"DsUnknown\" data-csa-c-slot-id=\"DsUnknown-6\" data-csa-c-type=\"widget\" data-csa-c-painter=\"tell-amazon-desktop-cards\" data-csa-c-id=\"m2bbau-730urt-9q7ms7-m0ixnx\" data-cel-widget=\"tell-amazon-desktop_DetailPage_5\"\u003e\n\u003cdiv id=\"CardInstancei2VOfo_vtBy8z3LWi2iuow\" data-card-metrics-id=\"tell-amazon-desktop_DetailPage_5\" data-acp-tracking=\"{}\" data-mix-claimed=\"true\"\u003e\n\u003cdiv data-asin=\"3030615065\" data-marketplace=\"ATVPDKIKX0DER\" data-logged-in=\"false\" class=\"_tell-amazon-desktop_style_tell_amazon_div__1YDZk\"\u003e\n\u003cdiv class=\"accordion-item\" id=\"acc-content\"\u003e\n\u003ch2 class=\"accordion-header\" id=\"flush-headingThree\"\u003eTable of Contents\u003c\/h2\u003e\n\u003cdiv id=\"flush-collapseThree\" class=\"accordion-collapse collapse show\" aria-labelledby=\"flush-headingThree\"\u003e\n\u003cdiv class=\"accordion-body\"\u003e\n\u003cp\u003e\u003cstrong\u003eChapter 1\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eEnergy of Intermolecular Interactions in Drug-Receptor Complex Formation\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cbr\u003eChapter 2\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eMethods for Studying Drug-Receptor Binding\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cbr\u003eChapter 3\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eMethods for Drug Discovery Research\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cbr\u003eChapter 4\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eThermodynamics of Drug-Receptor Complex Formation\u003cbr\u003e　\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eChapter 5\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eEffect of conformation entropy on affinity of specific ligands\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cbr\u003eChapter 6\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eKinetics of Drug-Receptor Complex Formation\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cbr\u003eChapter 7\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eDistant and Contact Interactions of Drugs with Specific and Non-specific Receptors\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cbr\u003eChapter 8\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eInfluence of bound water on interaction of the chemical groups in drugs and receptors\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cbr\u003eChapter 9\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eInformation Required for Receptor Recognition\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cbr\u003eChapter 10\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eAgonists and Antagonists\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cbr\u003eChapter 11.\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eNon-selective Drugs\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cbr\u003eChapter 12\u003c\/strong\u003e\u003cspan\u003e \u003c\/span\u003eSearch Paths for Novel Therapeutics\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"accordion-item\" id=\"acc-authors\"\u003e\n\u003ch2 class=\"accordion-header\" id=\"flush-headingFour\"\u003eAuthor(s)\u003c\/h2\u003e\n\u003cdiv id=\"flush-collapseFour\" class=\"accordion-collapse collapse show\" aria-labelledby=\"flush-headingFour\"\u003e\n\u003cdiv class=\"accordion-body\"\u003e\n\u003ch3\u003eBiography\u003c\/h3\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMikhail Borisovich Darkhovskiy\u003cspan\u003e \u003c\/span\u003e\u003c\/strong\u003egraduated from Moscow State University in 1996 with a major in Quantum Chemistry. In 2005 he earned a PhD in Chemistry and Solid-State Physics under the supervision of Dr. Andrei Thougreeff. His research was in electronic structure and transformation of spin- isomers of iron and cobalt complexes in spin transitions using the QM\/ MM effective crystal field method. Together with Professor Dukhovich, he investigated the factors involved in molecular recognition in “ligand–receptor” systems, the influence of water on complex strength, and conformational entropy as a hidden factor for complex formation. Currently, he works in the biotech startup InterX (a subsidiary of NeoTX company), participating in the development of methods for the accurate prediction of compounds’ binding affinity to proteins. His awards include the INTAS Young Scientist award, and, Emory University Visiting Scientist award (Cherry L. Emerson Center for Scientific Computation Fellowship).\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-cel-widget=\"hushpuppyUpsell_feature_div\" data-csa-c-id=\"pxjfta-fwstb7-c2nc0v-42bs92\" data-csa-c-is-in-initial-active-row=\"false\" data-csa-c-asin=\"\" data-csa-c-slot-id=\"hushpuppyUpsell_feature_div\" data-csa-c-content-id=\"hushpuppyUpsell\" data-csa-c-type=\"widget\" data-feature-name=\"hushpuppyUpsell\" class=\"celwidget\" id=\"hushpuppyUpsell_feature_div\"\u003e\u003c\/div\u003e\n\u003cdiv data-cel-widget=\"richProductInformation_feature_div\" data-csa-c-id=\"7yxy0j-6nwvf8-fxhfnf-km9iaf\" data-csa-c-is-in-initial-active-row=\"false\" data-csa-c-asin=\"\" data-csa-c-slot-id=\"richProductInformation_feature_div\" data-csa-c-content-id=\"richProductInformation\" data-csa-c-type=\"widget\" data-feature-name=\"richProductInformation\" class=\"celwidget\" id=\"richProductInformation_feature_div\"\u003e\n\u003cdiv data-cel-widget=\"rich_product_information\" data-csa-c-id=\"38ilu8-62uj6y-p8nl3f-bnje16\" class=\"a-section a-spacing-none celwidget\" id=\"rich_product_information\"\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv data-cel-widget=\"hushpuppyUpsell_feature_div\" data-csa-c-id=\"pxjfta-fwstb7-c2nc0v-42bs92\" data-csa-c-is-in-initial-active-row=\"false\" data-csa-c-asin=\"\" data-csa-c-slot-id=\"hushpuppyUpsell_feature_div\" data-csa-c-content-id=\"hushpuppyUpsell\" data-csa-c-type=\"widget\" data-feature-name=\"hushpuppyUpsell\" class=\"celwidget\" id=\"hushpuppyUpsell_feature_div\"\u003e\u003c\/div\u003e\n\u003cdiv data-cel-widget=\"richProductInformation_feature_div\" data-csa-c-id=\"7yxy0j-6nwvf8-fxhfnf-km9iaf\" data-csa-c-is-in-initial-active-row=\"false\" data-csa-c-asin=\"\" data-csa-c-slot-id=\"richProductInformation_feature_div\" data-csa-c-content-id=\"richProductInformation\" data-csa-c-type=\"widget\" data-feature-name=\"richProductInformation\" class=\"celwidget\" id=\"richProductInformation_feature_div\"\u003e\n\u003cdiv data-cel-widget=\"rich_product_information\" data-csa-c-id=\"38ilu8-62uj6y-p8nl3f-bnje16\" class=\"a-section a-spacing-none celwidget\" id=\"rich_product_information\"\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv\u003e\n\u003cdiv class=\"books-tags-wrap\"\u003e\u003cbr\u003e\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cb\u003eBOOKREAD™ 5-STEP SATISFACTION GUARANTEE\u003c\/b\u003e\u003c\/strong\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003e1. No Risk, 30-Day Money-Back Guarantee. \u003cbr\u003e2. instant download. No surprises or hidden fees.\u003cbr\u003e3. Safe Payments via Credit\/Debit Card or PayPal® \u003cbr\u003e4. McAfee™ and SSL secured shopping cart.\u003cbr\u003e5. lifetime customer support.\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","brand":"My Store","offers":[{"title":"PDF","offer_id":56778131177803,"sku":null,"price":29.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1031\/1204\/8971\/files\/71se6VjgCjL._SL1500.jpg?v=1773316590","url":"https:\/\/bookread.io\/products\/molecular-recognition-in-pharmacology-drugs-and-the-pharmaceutical-sciences-1st-edition","provider":"bookread","version":"1.0","type":"link"}