{"product_id":"praziquantel-discovery-and-development-of-an-anthelmintic-drug","title":"Praziquantel: Discovery and Development of an Anthelmintic Drug","description":"\u003cdiv id=\"bookDescription_feature_div\" class=\"celwidget\" data-feature-name=\"bookDescription\" data-csa-c-type=\"widget\" data-csa-c-content-id=\"bookDescription\" data-csa-c-slot-id=\"bookDescription_feature_div\" data-csa-c-asin=\"0993745598\" data-csa-c-is-in-initial-active-row=\"false\" data-csa-c-id=\"7y9w7h-rgk3d4-2xixgp-6jetc1\" data-cel-widget=\"bookDescription_feature_div\"\u003e\n\u003cdiv data-a-expander-name=\"book_description_expander\" data-a-expander-collapsed-height=\"280\" class=\"a-expander-collapsed-height a-row a-expander-container a-spacing-base a-expander-partial-collapse-container\"\u003e\n\u003cdiv aria-expanded=\"false\" class=\"a-expander-content a-expander-partial-collapse-content\"\u003e\n\u003cp\u003e\u003cspan\u003eThis open-access book provides a comprehensive reference on the discovery and development of praziquantel. It presents the full research and development (R\u0026amp;D) journey of this essential anthelmintic drug, combining foundational science with practical insights.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eThe book covers a wide range of topics, including a brief history of pharmaceutical industry, unmet medical needs, parasitic flatworm biology, and strategies for schistosomiasis control and elimination. Both human and animal health applications are addressed. Additional chapters explore chemical and manufacturing aspects, drug targets, biomarkers, toxicology, clinical efficacy, regulatory pathways, and Intellectual Property considerations. Rich illustrations, expert commentary, and clear summaries enhance the educational value of the text. \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eDesigned for students, academics, and industry professionals alike, this volume serves as a valuable addition to any scientific library. It also supports the United Nations Sustainable Development Goal 3 (Good Health and Well-being) by contributing to the global fight against schistosomiasis and other Neglected Tropical Diseases.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e Table of contents (12 chapters)\u003c\/strong\u003e\u003cbr\u003eFront Matter\u003cbr\u003ePages i-xvii\u003cbr\u003eA Brief History of the Pharmaceutical Industry\u003cbr\u003eDiego González Cabrera, Paul M. Selzer, Thomas Spangenberg\u003cbr\u003ePages 1-20\u003cbr\u003eOpen Access\u003cbr\u003eThe Parasite’s Life Cycle and the Patient\u003cbr\u003eJoachim Richter, Clarissa Prazeres da Costa\u003cbr\u003ePages 21-39\u003cbr\u003eOpen Access\u003cbr\u003eThe Medical Need for Patients with Schistosomiasis\u003cbr\u003eNicola Caldwell, Ian Gilbert\u003cbr\u003ePages 41-63\u003cbr\u003eOpen Access\u003cbr\u003eFrom Small Molecule to Drug Product: The Chemical Journey of Praziquantel\u003cbr\u003eDavid Maillard, Thomas Spangenberg, Yara Sylla\u003cbr\u003ePages 65-84\u003cbr\u003eOpen Access\u003cbr\u003eThe Molecular Drug Target of Praziquantel\u003cbr\u003eSang-Kyu Park, Daniel J. Sprague, Jonathan S. Marchant\u003cbr\u003ePages 85-105\u003cbr\u003eOpen Access\u003cbr\u003eIn Vitro and In Vivo Activity of Praziquantel Against Schistosome Worms\u003cbr\u003eThomas Spangenberg, Jennifer Keiser\u003cbr\u003ePages 107-123\u003cbr\u003eOpen Access\u003cbr\u003eIn Life Behavior of Praziquantel and Relationship Between Drug Exposure and Effect\u003cbr\u003eMathew Njoroge, Peter Ballard\u003cbr\u003ePages 125-144\u003cbr\u003eOpen Access\u003cbr\u003eNonclinical Safety\u003cbr\u003eClaudia Demarta-Gatsi, Christian Brenneis, Philip Hewitt, Nicole Hübler, Stefan Weigt\u003cbr\u003ePages 145-173\u003cbr\u003eOpen Access\u003cbr\u003eControlled Human Schistosoma mansoni Infection Model and Biomarkers\u003cbr\u003eMarie-Astrid Hoogerwerf, Meta Roestenberg\u003cbr\u003ePages 175-191\u003cbr\u003eOpen Access\u003cbr\u003eClinical Efficacy of Praziquantel on Schistosoma Infections\u003cbr\u003eWilhelmina M. Bagchus\u003cbr\u003ePages 193-213\u003cbr\u003eOpen Access\u003cbr\u003eRegulators’ Viewpoint\u003cbr\u003eKatja Schüz\u003cbr\u003ePages 215-233\u003cbr\u003eOpen Access\u003cbr\u003eProprietary Aspects of Praziquantel\u003cbr\u003eArno Hartmann\u003cbr\u003ePages 235-253\u003cbr\u003eOpen Access\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eAbout the editor\u003c\/strong\u003e\u003cbr\u003eThomas Spangenberg, PhD - With Merck since 2015, Thomas is heading global health research and leads drug discovery programs from drug screening to preclinical candidate nomination. He drives translation research by generating Real-World Data to support clinical candidates and catalyses research in infectious diseases through open innovation initiatives. Prior to joining Merck, Thomas was part of the drug discovery team at non-for-profit R\u0026amp;D organization Medicines for Malaria Venture (Switzerland), where he led the open-source Malaria Box and Pathogen Box initiatives aimed at accelerating drug discovery for infectious diseases.\u003c\/p\u003e\n\u003cp\u003eThomas holds a PhD in organic chemistry from the Universities of Strasbourg (France) and Freiburg im Breisgau (Germany). In 2009, he became a post-doctoral fellow at Harvard University (USA), contributing to the total synthesis of mycolactones and advancing point-of-care diagnostics for Buruli ulcer, a neglected necrotizing skin disease. He has authored and co-authored over 50 peer-reviewed articles and is a co-inventor on several patents.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cb\u003eBOOKREAD™ 5-STEP SATISFACTION GUARANTEE\u003c\/b\u003e\u003c\/strong\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e\u003cstrong\u003e1. No Risk, 30-Day Money-Back Guarantee. \u003cbr\u003e2. instant download. No surprises or hidden fees.\u003cbr\u003e3. Safe Payments via Credit\/Debit Card or PayPal® \u003cbr\u003e4. McAfee™ and SSL secured shopping cart.\u003cbr\u003e5. lifetime customer support.\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","brand":"My Store","offers":[{"title":"PDF","offer_id":56778050568523,"sku":null,"price":29.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1031\/1204\/8971\/files\/81VfDhsI45L._SL1500.jpg?v=1773315860","url":"https:\/\/bookread.io\/products\/praziquantel-discovery-and-development-of-an-anthelmintic-drug","provider":"bookread","version":"1.0","type":"link"}