Definitive reference on studying proteome biomarkers through cardiovascular disease pathophysiology and applied mass spectrometry
Cardiovascular Proteomics Techniques explores the intersection of cardiovascular disease pathophysiology and applied mass spectrometry to study proteome biomarkers. Leading experts provide a comprehensive overview of the physiopathology of cardiovascular system diseases, along with insights into their etiology and pathogenesis through proteomics. The book features 18 chapters covering a range of topics, including mass spectrometry, proteomics, atherosclerosis, heart biology, cardiovascular diseases, experimental models, network analysis, international proteomic initiatives, clinical proteomics, and sex and gender proteomics.
Cardiovascular Proteomics Techniques also includes in depth discussions on:
- Antibody-based technologies for multiplexed protein detection and quantification, and their complementary role to mass spectrometry-based protein profiling.
- New findings from proteomic analysis regarding the pathogenesis of atherosclerosis.
- Emerging insights into the pathobiology of acute coronary syndromes.
- Network medicine as a new paradigm for cardiovascular disease research and beyond, with potential applications in drug repurposing.
- Recent advances in cardiovascular plasma proteomics and previously unexplored cardiac diseases, such as Takotsubo syndrome.
This book is ideal for researchers in mass spectrometry, proteomics, life sciences, and cardiovascular studies, Cardiovascular Proteomics Techniques aims to enhance our understanding of cardiovascular issues among clinicians and stimulate future developments in proteomics for the diagnosis and treatment of cardiovascular diseases.
Table of Contents
Front Matter (Pages: i-xxv)
CHAPTER 1
Basic Concepts in Mass Spectrometry (Pages: 1-30)
CHAPTER 2
Overview of Antibody-Based Technologies for Multiplexed Protein Detection and Quantification and Their Complementarity to Mass Spectrometry-Based Protein Profiling (Pages: 31-63)
CHAPTER 3
General Features of the Cardiovascular System (Pages: 65-77)
CHAPTER 4
Albumin and Cardiovascular Diseases (Pages: 79-105)
CHAPTER 5
Platelets: From Biomarker Discovery to Drug Target Identification by Proteomics (Pages: 107-138)
CHAPTER 6
The Role of Proteomics in Extracellular Vesicles Research in Cardiovascular Disease (Pages: 139-176)
CHAPTER 7
Proteomics of Human Lipoproteins in Cardiovascular Diseases (Pages: 177-214)
CHAPTER 8
Extracellular Matrix in Cardiovascular Pathophysiology: Proteomic Insights and Advancements to Mass Spectrometry-Based Characterization (Pages: 215-253)
CHAPTER 9
Pathogenesis of Atherosclerosis: What We are Learning from Proteomics (Pages: 255-281)
CHAPTER 10
Emerging Insights into the Pathobiology of Acute Coronary Syndromes (Pages: 283-312)
CHAPTER 11
Valvular Heart Disease, from Physiopathology to Biomarker Discovery (Pages: 313-340)
CHAPTER 12
Pathophysiology of Heart Failure (Pages: 341-369)
CHAPTER 13
Diseases of the Aorta, Recent Insights (Pages: 371-390)
CHAPTER 14
Unveiling Sex and Gender Differences in Cardiovascular Diseases (Pages: 391-429)
CHAPTER 15
Trends in Mass Spectrometry Imaging for Cardiovascular Diseases (Pages: 431-447)
CHAPTER 16
Network Medicine: A New Paradigm for Cardiovascular Disease Research and Beyond (Pages: 449-485)
CHAPTER 17
Recent Advances in Cardiovascular Plasma Proteomics (Pages: 487-522)
CHAPTER 18
Unexplored Cardiac Diseases: Takotsubo Syndrome (Pages: 523-539)
Index (Pages: 541-549)
First Page
